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| Stereoselective absorption，elimination，and transformation of chiral fungicide difenoconazole in an earthworm-soil system |
| Received:March 08, 2024 |
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| KeyWord:difenoconazole;enantioselectivity;bioaccumulation;transformation product;degradation pathway |
| Author Name | Affiliation | E-mail | | WANG Jiafu | Key Laboratory for Environmental Factors Control of Agro-product Quality Safety, Ministry of Agriculture and Rural Affairs, Tianjin 300191, China
Agro-Environmental Protection Institute, Ministry of Agriculture and Rural Affairs, Tianjin 300191, China | | | FU Jiqiang | Key Laboratory for Environmental Factors Control of Agro-product Quality Safety, Ministry of Agriculture and Rural Affairs, Tianjin 300191, China
Agro-Environmental Protection Institute, Ministry of Agriculture and Rural Affairs, Tianjin 300191, China | | | WANG Jishi | Key Laboratory for Environmental Factors Control of Agro-product Quality Safety, Ministry of Agriculture and Rural Affairs, Tianjin 300191, China
Agro-Environmental Protection Institute, Ministry of Agriculture and Rural Affairs, Tianjin 300191, China | | | ZHANG Yanwei | Key Laboratory for Environmental Factors Control of Agro-product Quality Safety, Ministry of Agriculture and Rural Affairs, Tianjin 300191, China
Agro-Environmental Protection Institute, Ministry of Agriculture and Rural Affairs, Tianjin 300191, China | | | GENG Yue | Key Laboratory for Environmental Factors Control of Agro-product Quality Safety, Ministry of Agriculture and Rural Affairs, Tianjin 300191, China
Agro-Environmental Protection Institute, Ministry of Agriculture and Rural Affairs, Tianjin 300191, China | | | HE Zeying | Key Laboratory for Environmental Factors Control of Agro-product Quality Safety, Ministry of Agriculture and Rural Affairs, Tianjin 300191, China
Agro-Environmental Protection Institute, Ministry of Agriculture and Rural Affairs, Tianjin 300191, China | hezeying@caas.cn |
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| Abstract: |
| This study was conducted to comprehensively explore the enantioselective environmental behavior of the triazole fungicide difenoconazole in the earthworm-soil system. Laboratory experiments were performed to study the bioaccumulation, elimination, and degradation pathways of chiral difenoconazole. Four stereoisomers of difenoconazole were separated and determined by SFC-MS/MS. Significant enantioselectivity was observed during the accumulation phase, and（2R, 4R）-difenoconazole and（2R, 4S）-difenoconazole were preferentially accumulated in earthworms. Five transformation products（TPs）were identified by UHPLC-QTOF/MS, namely 3- chloro, 4-hydroxy difenoconazole, CGA-205374, CGA-205375, 3-chloro, 4-hydroxy CGA-205375, and CGA-71019（1, 2, 4-triazole）. The main transformation pathways observed for difenoconazole in earthworms and soil were hydrolysis and hydroxylation. Furthermore, the chiral transformation product, 3-chloro, 4-hydroxy difenoconazole, was generated with significant enantioselectivity. |
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