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| Study of toxicity of Caenorhabditis elegans exposed to nonylphenol solution |
| Received:May 23, 2017 |
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| KeyWord:nonylphenol;Caenorhabditis elegans;ecological toxicology |
| Author Name | Affiliation | E-mail | | LI An | Beijing Research Center for Agricultural Standards and Testing, Beijing 100097, China
Risk Assessment Lab of Agri-products Quality and Safety of Ministry of Agriculture(Beijing), Beijing 100097, China | | | PAN Li-gang | Beijing Research Center for Agricultural Standards and Testing, Beijing 100097, China
Risk Assessment Lab of Agri-products Quality and Safety of Ministry of Agriculture(Beijing), Beijing 100097, China | panlg@brcast.org.cn | | ZHANG Xiu-tong | Beijing Research Center for Agricultural Standards and Testing, Beijing 100097, China
Risk Assessment Lab of Agri-products Quality and Safety of Ministry of Agriculture(Beijing), Beijing 100097, China | | | LIANG Gang | Beijing Research Center for Agricultural Standards and Testing, Beijing 100097, China
Risk Assessment Lab of Agri-products Quality and Safety of Ministry of Agriculture(Beijing), Beijing 100097, China | | | MAN Yan | Beijing Research Center for Agricultural Standards and Testing, Beijing 100097, China
Risk Assessment Lab of Agri-products Quality and Safety of Ministry of Agriculture(Beijing), Beijing 100097, China | | | JIN Xin-xin | Beijing Research Center for Agricultural Standards and Testing, Beijing 100097, China
Risk Assessment Lab of Agri-products Quality and Safety of Ministry of Agriculture(Beijing), Beijing 100097, China | |
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| Abstract: |
| To better understand the effect of acute lethal toxicity and non-lethal toxicity on Caenorhabditis elegans exposed to nonylphenol solution, C. elegans were exposed to nonylphenol solution for 24 h and then toxicity indicators such as lethal concentration, development of a gonad arm, number of offspring, body length, and body bending frequency were investigated. Results showed that the median lethal concentration LC50 for 24 h acute exposure was 8.09 mg·L-1 when using L4 wild-type C. elegans as the testing animal. Nonylphenol can interfere with the normal development of the gonad arm of C. elegans. Compared with the control, both the 0.081 mg·L-1 and 0.162 mg·L-1 of nonylphenol treatment had significant effects on the number of offspring in C. elegans and the body length of the worm (P<0.05). The body bending frequency of C. elegans exposed to low doses of nonylphenol showed no statistical difference compared with the control (P>0.05), whereas high dose treatment showed significant difference (P<0.05). The results of the toxicity experiments indicate that the model animal C. elegans has certain sensitivity to nonylphenol. Thus, using C. elegans as a model animal has potential application value in the ecological toxicology of environmental hormones. |
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