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| Acute toxicity of cyfluthrin and its effect on transaminase activity in grass carp (Ctenopharyngodon idellus) |
| Received:June 09, 2017 |
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| KeyWord:Ctenopharyngodon idellus;cyfluthrin;ALT;AST |
| Author Name | Affiliation | E-mail | | WANG Wei | Key Laboratory of Aquatic Science of Chongqing, College of Animal Science and Technology, Southwest University, Chongqing 400715, China | | | CHAI Jing | Suining Institute Product Quality Supervision & Inspection, Suining 629000, China | | | SUN Han-chang | College of Forestry and Life Science, Chongqing University of Arts and Sciences, Chongqing 402160, China | | | DING Shi-hua | Key Laboratory of Aquatic Science of Chongqing, College of Animal Science and Technology, Southwest University, Chongqing 400715, China | 1031288162@qq.com |
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| Abstract: |
| Cyfluthrin is a widely used pesticide in agriculture, but its potential toxicity to aquatic animals is not well understood. In this study, the effects of different concentrations of cyfluthrin (0, 0.2, 0.4, 0.6, 0.8 μg·L-1) on the activities of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in the liver and kidney of grass carp (Ctenopharyngodon idellus) were studied. The results showed that the 96 h LC50 (median lethal concentration) of cyfluthrin was 1.112 μg·L-1. In the early exposure stage, cyfluthrin induced the activities of ALT and AST and there was a positive correlation between cyfluthrin concentration and induction effects. After 1 day of exposure to 0.8 μg·L-1 cyfluthrin, the ALT activity in the liver and kidney increased by 28.12% and 26.74%, respectively, and the AST activity increased by 31.45% and 22.56%, respectively. However, the activities of AST and ALT were inhibited as exposure time increased, and the inhibitory effects increased with cyfluthrin concentration. The activities of ALT and AST in the liver and kidney were significantly decreased after 10 days of exposure to 0.8 μg·L-1 cyfluthrin. Following cyfluthrin exposure, changes in ALT and AST activities in the liver were more obvious than those in the kidney. These results showed that sublethal concentrations of cyfluthrin induced changes in ALT and AST activities in the liver and kidney, suggesting that cyfluthrin contaminants affect the physiological function and have toxic effects on the liver and kidney of grass carp. |
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