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| Thyroid hormone-disrupting effects of hexabromocyclododecane in zebrafish(Danio rerio) |
| Received:April 08, 2017 |
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| KeyWord:hexabromocyclododecane;zebrafish;thyroid hormone;disruption |
| Author Name | Affiliation | E-mail | | LIU Xiao-yan | Key Laboratory of Subsurface Hydrology and Ecological Effects in Arid Region of Ministry of Education, Chang'an University, Xi'an 710064, China
South China Institutes of Environmental Sciences, Ministry of Environmental Protection, Guangzhou 510535, China
State Environmental Protection Key Laboratory of Environmental Pollution Health Risk Assessment, Guangzhou 510535, China | | | LIU Shan | Key Laboratory of Subsurface Hydrology and Ecological Effects in Arid Region of Ministry of Education, Chang'an University, Xi'an 710064, China | | | ZHANG Li-juan | South China Institutes of Environmental Sciences, Ministry of Environmental Protection, Guangzhou 510535, China
State Environmental Protection Key Laboratory of Environmental Pollution Health Risk Assessment, Guangzhou 510535, China | | | HAN Qian | Shenzhen Academy of Environmental Sciences, Shenzhen 518001, China | | | CHEN Mian-biao | South China Institutes of Environmental Sciences, Ministry of Environmental Protection, Guangzhou 510535, China
State Environmental Protection Key Laboratory of Environmental Pollution Health Risk Assessment, Guangzhou 510535, China | | | HUANG Chu-shan | South China Institutes of Environmental Sciences, Ministry of Environmental Protection, Guangzhou 510535, China
State Environmental Protection Key Laboratory of Environmental Pollution Health Risk Assessment, Guangzhou 510535, China | | | WEI Dong-yang | South China Institutes of Environmental Sciences, Ministry of Environmental Protection, Guangzhou 510535, China
State Environmental Protection Key Laboratory of Environmental Pollution Health Risk Assessment, Guangzhou 510535, China | | | HU Guo-cheng | South China Institutes of Environmental Sciences, Ministry of Environmental Protection, Guangzhou 510535, China
State Environmental Protection Key Laboratory of Environmental Pollution Health Risk Assessment, Guangzhou 510535, China | huguocheng@scies.org |
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| Abstract: |
| Hexabromocyclododecane(HBCD) is a brominated flame retardant, and has become a ubiquitous pollutant of the environment. To explore the thyroid hormone-disrupting effects of long-term dietary exposure to HBCD, adult zebrafish were exposed to different concentrations of the chemical(0, 10, 100 ng·g-1, and 400 ng·g-1) for 56 days to determine triiodothyronine(T3), tetraiodothyronine(T4), free triiodothyronine(FT3), and free tetraiodothyronine(FT4) levels, and T3/T4 ratios in the liver tissues of zebrafish. The results showed that HBCD disrupted the action of the thyroid hormone in zebrafish. The levels of T3 and T4 in the liver tissues of the zebrafish decreased significantly with increasing concentrations of HBCD. Significant inhibitory effects on FT3 and FT4 were observed in the 100 ng·g-1 and 400 ng·g-1 exposure groups(P<0.01). Moreover, the T3/T4 ratio in the liver tissues increased with increasing HBCD concentration. This result indicated that HBCD could transform T4 into T3. In summary, our findings showed that HBCD could affect thyroid function and homeostatic levels in zebrafish, and could further influence the growth and development of zebrafish. |
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