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| Joint Toxicity of Cyanogenic Chemicals and Aldehydes to Photobacterium phosphoreum |
| Received:January 18, 2015 |
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| KeyWord:cyanogenic chemicals;aldehyde compounds;Photobacterium phosphoreum;acute joint toxicity;QSAR model |
| Author Name | Affiliation | E-mail | | HUA Wen-feng | College of Fisheries and Life Science, Shanghai Ocean University, Shanghai 201306, China | | | TIAN Da-yong | State Key Laboratory of Pollution Control and Resource Reuse, College of Environmental Science and Engineering, Tongji University, Shanghai 200092, China | | | AN Qing-qing | College of Marine Sciences, Shanghai Ocean University, Shanghai 201306, China | | | LIN Zhi-fen | State Key Laboratory of Pollution Control and Resource Reuse, College of Environmental Science and Engineering, Tongji University, Shanghai 200092, China | | | ZHANG Yin-jiang | College of Fisheries and Life Science, Shanghai Ocean University, Shanghai 201306, China
Engineering Research Center for Water Environment Ecology in Shanghai, Shanghai Ocean University, Shanghai 201306, China | yjzhang@shou.edu.cn |
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| Abstract: |
| It is widely accepted that organisms are often exposed to mixtures of multiple pollutants rather than to single chemical in the environment, such as cyanogenic chemicals and aldehydes. The interactions among the components in the pollutant mixtures might cause substantial changes in their apparent properties, leading to additive, synergistic or antagonistic effects, and thus posing potential threats on the environmental safety and human health. In this paper, cyanogenic chemicals and aldehydes were selected as the research chemicals and Photobacterium phosphoreum as a model organism. The acute toxicity of cyanogenic and aldehyde compounds to Photobacterium phosphoreum was tested based on the light emitting reaction in bioluminescence. General approaches were therefore proposed to predict the biological toxicity of chemical mixtures with different toxicity processes by using effective carbon charge and substituent constant. The QSAR models for acute toxicity of cyanogenic chemicals and aldehydes alone and in mixture were established. The mechanisms of mixed toxicity of cyanogenic chemicals and aldehydes were suggested. Results demonstrated that the joint toxicity changed with different mixtures of cyanogenic chemicals and aldehydes, which showed additive and synergistic effects. This work would provide basic information for the joint ecological risk assessment and remediation of cyanogenic chemicals and aldehydes. |
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