| 王伟,柴菁,孙翰昌,丁诗华.氟氯氰菊酯对草鱼的急性毒性及转氨酶活性的影响[J].农业环境科学学报,2017,36(12):2388-2393. |
| 氟氯氰菊酯对草鱼的急性毒性及转氨酶活性的影响 |
| Acute toxicity of cyfluthrin and its effect on transaminase activity in grass carp (Ctenopharyngodon idellus) |
| 投稿时间：2017-06-09 |
| DOI：10.11654/jaes.2017-0817 |
| 中文关键词: 草鱼 氟氯氰菊酯 谷丙转氨酶 谷草转氨酶 |
| 英文关键词: Ctenopharyngodon idellus cyfluthrin ALT AST |
| 基金项目:重庆市科委社会事业与民生保障科技创新项目（cstc2015shmszx80032） |
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| 中文摘要: |
| 为了揭示氟氯氰菊酯对水生动物的毒性效应，本研究采用静水暴露法分析不同浓度氟氯氰菊酯（0、0.2、0.4、0.6、0.8 μg·L-1）对草鱼肝肾谷丙转氨酶（Alanine aminotransferase，ALT）、谷草转氨酶（Aspartate aminotransferase，AST）活性的影响。研究结果显示，氟氯氰菊酯对草鱼96 h LC50为1.112 μg·L-1。在暴露初始阶段，氟氯氰菊酯对ALT、AST活性具有诱导作用，浓度越高诱导作用越显著。其中0.8 μg·L-1氟氯氰菊酯处理1 d后，肝脏、肾脏ALT活性分别上升28.12%、26.74%，AST活性分别上升31.45%、22.56%；但随着暴露时间延长，氟氯氰菊酯对肝肾ALT、AST活性表现出抑制作用，且高浓度（0.8 μg·L-1）氟氯氰菊酯的抑制作用极显著，暴露10 d后肝肾ALT、AST活性有显著下降。与肾脏相比，氟氯氰菊酯处理后肝脏ALT、AST活性变化更明显。本研究结果表明，亚致死浓度的氟氯氰菊酯可引起肝肾ALT、AST活性变化，提示氟氯氰菊酯污染物可影响草鱼肝肾的生理功能，对肝肾具有一定的毒性效应。 |
| 英文摘要: |
| Cyfluthrin is a widely used pesticide in agriculture, but its potential toxicity to aquatic animals is not well understood. In this study, the effects of different concentrations of cyfluthrin (0, 0.2, 0.4, 0.6, 0.8 μg·L-1) on the activities of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in the liver and kidney of grass carp (Ctenopharyngodon idellus) were studied. The results showed that the 96 h LC50 (median lethal concentration) of cyfluthrin was 1.112 μg·L-1. In the early exposure stage, cyfluthrin induced the activities of ALT and AST and there was a positive correlation between cyfluthrin concentration and induction effects. After 1 day of exposure to 0.8 μg·L-1 cyfluthrin, the ALT activity in the liver and kidney increased by 28.12% and 26.74%, respectively, and the AST activity increased by 31.45% and 22.56%, respectively. However, the activities of AST and ALT were inhibited as exposure time increased, and the inhibitory effects increased with cyfluthrin concentration. The activities of ALT and AST in the liver and kidney were significantly decreased after 10 days of exposure to 0.8 μg·L-1 cyfluthrin. Following cyfluthrin exposure, changes in ALT and AST activities in the liver were more obvious than those in the kidney. These results showed that sublethal concentrations of cyfluthrin induced changes in ALT and AST activities in the liver and kidney, suggesting that cyfluthrin contaminants affect the physiological function and have toxic effects on the liver and kidney of grass carp. |
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