| 花文凤,田大勇,安情情,林志芬,张饮江.腈醛混合物对明亮发光杆菌联合毒性效应[J].农业环境科学学报,2015,34(6):1047-1052. |
| 腈醛混合物对明亮发光杆菌联合毒性效应 |
| Joint Toxicity of Cyanogenic Chemicals and Aldehydes to Photobacterium phosphoreum |
| 投稿时间：2015-01-18 |
| DOI：10.11654/jaes.2015.06.005 |
| 中文关键词: 腈类化合物 醛类化合物 明亮发光杆菌 急性联合毒性 QSAR模型 |
| 英文关键词: cyanogenic chemicals aldehyde compounds Photobacterium phosphoreum acute joint toxicity QSAR model |
| 基金项目:国家自然科学面上基金(201177092);同济大学污染控制与资源化研究国家重点实验室自主研究重点项目(PCRRY11003);高等学校博士学科点专项科研基金课题(20100072110034) |
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| 中文摘要: |
| 选取腈化合物和醛化合物为研究对象, 以明亮发光杆菌为模式生物, 以15 min发光抑制为测定终点, 测定了10种腈醛化合物的单一急性毒性和55组二元非等毒性比腈醛混合体系的联合毒性, 分别建立了腈、醛化合物单一急性毒性的QSAR模型, 并提出了非等毒性比腈醛混合化合物对发光菌联合毒性的QSAR模型。结果表明, 不同的腈醛混合化合物对发光菌的联合毒性不同, 主要呈现协同作用和相加作用。采用QSAR模型定量描述了腈醛类化合物对明亮发光杆菌的联合毒性作用, 为环境介质中腈醛的联合生态风险评价和修复提供了理论依据。 |
| 英文摘要: |
| It is widely accepted that organisms are often exposed to mixtures of multiple pollutants rather than to single chemical in the environment, such as cyanogenic chemicals and aldehydes. The interactions among the components in the pollutant mixtures might cause substantial changes in their apparent properties, leading to additive, synergistic or antagonistic effects, and thus posing potential threats on the environmental safety and human health. In this paper, cyanogenic chemicals and aldehydes were selected as the research chemicals and Photobacterium phosphoreum as a model organism. The acute toxicity of cyanogenic and aldehyde compounds to Photobacterium phosphoreum was tested based on the light emitting reaction in bioluminescence. General approaches were therefore proposed to predict the biological toxicity of chemical mixtures with different toxicity processes by using effective carbon charge and substituent constant. The QSAR models for acute toxicity of cyanogenic chemicals and aldehydes alone and in mixture were established. The mechanisms of mixed toxicity of cyanogenic chemicals and aldehydes were suggested. Results demonstrated that the joint toxicity changed with different mixtures of cyanogenic chemicals and aldehydes, which showed additive and synergistic effects. This work would provide basic information for the joint ecological risk assessment and remediation of cyanogenic chemicals and aldehydes. |
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