| 兰砥中,雷鸣,周爽,廖柏寒,崔岩山,尹乃毅,沈跃.体外模拟实验法评价湘南某矿区大米中重金属的人体健康风险[J].农业环境科学学报,2014,33(10):1897-1903. |
| 体外模拟实验法评价湘南某矿区大米中重金属的人体健康风险 |
| Health Risk Assessment of Heavy Metals in Rice Grains from A Mining-Impacted Area in South Hunan by in Vitro Simulation Method |
| 投稿时间：2014-04-09 |
| DOI：10.11654/jaes.2014.10.004 |
| 中文关键词: 矿区 大米 体外模拟实验法 重金属 生物可给量 健康风险 |
| 英文关键词: mining-impacted area rice in vitro simulated method heavy metals amount of bio-availability health risk |
| 基金项目:国家863项目子课题（2012AA101404-5）；环保部公益基金（201009047）；国家自然科学基金（21007014/B0702） |
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| 中文摘要: |
| 为了评价大米中重金属对人体健康风险的影响，在湘南某矿区和非矿区采集大米样品，运用人工模拟实验方法，评价大米中 Pb、Zn、Cu、Cd和As的摄入量和生物可给量。结果表明：矿区大米重金属Pb、Zn、Cu、Cd和As的含量分别为2.03、30.08、6.57、2.34、3.80 mg·kg-1，非矿区大米重金属含量分别为1.03、8.65、1.52、0.15、0.30 mg·kg-1，成人和儿童因食用矿区大米而摄入的Pb（789.23、562.00 μg·d-1）、Zn（11 701.12、8 332.16 μg·d-1）、Cu（2 555.73、1 819.89 μg·d-1）、Cd（910.26、648.18 μg·d-1）和As（1 478.20、1 052.60 μg·d-1）超过因食用非矿区大米而摄入的Pb（400.67、285.31 μg·d-1）、Zn（3 364.57、2 395.84 μg·d-1）、Cu（591.18、420.97 μg·d-1）、Cd（58.51、41.67 μg·d-1）和As（116.70、83.10 μg·d-1）.模拟成人和儿童胃阶段和小肠阶段，矿区大米中Pb、Zn、Cu、Cd和As的平均生物可给量都大于非矿区大米中重金属的平均生物可给量；模拟胃阶段矿区大米中Pb、Zn、Cu、Cd和As的平均生物可给量都大于模拟小肠阶段重金属的平均生物可给量。在模拟胃消化阶段，矿区大米中Cd的生物可给量分别是每周可耐受摄入量的3.11倍（成人）和4.42倍（儿童）；在模拟小肠阶段，对于成人矿区大米中Pb、Cd和As的生物可给量没有超过每周可耐受摄入量，而对于儿童矿区大米中Pb和Cd的生物可给量都超过了每周可耐受摄入量。因此，矿区成人和儿童通过食用该区域大米将会对其身体产生健康风险，其中对儿童的健康危害更加明显。 |
| 英文摘要: |
| Human health risk of heavy metals(Pb, Zn, Cu, Cd and As) in rice grains collected from a mining-impacted area and a non-contaminated area in South Hunan Province was assessed using in vitro simulation method in the present study. The contents of Pb,Zn,Cu,Cd and As in rice grains were respectively 2.03 mg ·kg-1, 30.08 mg·kg-1, 6.57 mg·kg-1, 2.34 mg·kg-1 and 3.8 mg·kg-1 from the mining-impacted area and 1.03 mg·kg-1, 8.65 mg·kg-1, 1.52 mg·kg-1, 0.15 mg· kg-1 and 0.30 mg·kg-1 from the non-contaminated area. The acceptable daily intakes(ADI) of Pb, Zn, Cu, Cd and As for an adult and a child through the consumption of the rice grains from the mining-impacted area were Pb789.23 μg·d-1 and 562.00 μg·d-1, Zn 11 701.12 μg·d-1 and 8 332.16 μg·d-1, Cu 2 555.73 μg·d-1 and 1 819.89 μg·d-1, Cd 910.26 μg·d-1 and 648.18 μg·d-1, and As 1 478.20 and 1 052.60 μg·d-1, much higher than those from non- contaminated area(Pb 400.67 μg·d-1 and 285.31 μg·d-1, Zn 3 364.57 μg·d-1 and 2 395.84 μg·d-1, Cu 591.18 μg·d-1 and 420.97 μg·d-1, Cd 58.51 μg· d-1 and 41.67 μg·d-1, and As 116.70 μg·d-1 and 83.10 μg·d-1), respectively. Both gastric phase and intestinal stage stimulation showed that average bio -availability of Pb, Zn, Cu, Cd and As in rice grains was much higher from the mining impacted area than from the non-contaminated area, with greater bioavailability at the simulated gastric phase than at simulated intestinal stage. The bioavailability of Cd at simulated gastric phase was 3.11 times(for an adult) and 4.42 times(for a child) as much as that of the biologically tolerable weekly intake. At the simulated intestinal stage, the bio-availability of Pb, Cd, and As in rice grains from the mining impacted area was lower than the tolerable weekly intake for adults, but exceeded that for children. These findings show that consuming rice grains from mining-impacted area would pose health risk to human beings, specially children. |
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