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| Rapid determination of 41 primary aromatic amines in water by ultra high-performance liquid chromatography-tandem mass spectrometry with direct injection |
| Received:January 19, 2020 |
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| KeyWord:water;primary aromatic amines;aniline;liquid chromatography-tandem mass spectrometry |
| Author Name | Affiliation | E-mail | | WANG Lu | Key Laboratory of Environmental Factor Control for Agro-product Safety, Ministry of Agriculture and Rural Affairs/Agro-Environmental Protection Institute, Ministry of Agriculture and Rural Affairs, Tianjin 300191, China | | | HE Ze-ying | Key Laboratory of Environmental Factor Control for Agro-product Safety, Ministry of Agriculture and Rural Affairs/Agro-Environmental Protection Institute, Ministry of Agriculture and Rural Affairs, Tianjin 300191, China | | | SUN Xiao-jie | SCIEX, Shanghai 200335, China | | | SHI Xiao-meng | Key Laboratory of Environmental Factor Control for Agro-product Safety, Ministry of Agriculture and Rural Affairs/Agro-Environmental Protection Institute, Ministry of Agriculture and Rural Affairs, Tianjin 300191, China | | | HE Pei-qiao | Key Laboratory of Environmental Factor Control for Agro-product Safety, Ministry of Agriculture and Rural Affairs/Agro-Environmental Protection Institute, Ministry of Agriculture and Rural Affairs, Tianjin 300191, China | | | WANG Ce | Key Laboratory of Environmental Factor Control for Agro-product Safety, Ministry of Agriculture and Rural Affairs/Agro-Environmental Protection Institute, Ministry of Agriculture and Rural Affairs, Tianjin 300191, China | | | LIU Xiao-wei | Key Laboratory of Environmental Factor Control for Agro-product Safety, Ministry of Agriculture and Rural Affairs/Agro-Environmental Protection Institute, Ministry of Agriculture and Rural Affairs, Tianjin 300191, China | xwliu2006@163.com |
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| Abstract: |
| A ultra high-performance liquid chromatography-tandem mass spectrometric(UPLC-MS/MS)method was developed for the simultaneous determination of 41 primary aromatic amines(PAAs)in water. The samples were not purified, and were filtered through a 0.22 μm microporous membrane. The target compounds were separated on a Phenomenex Kinetex F5(3 mm×100 mm; 2.6 μm)column by gradient elution using 0.05% formic acid-methanol as the mobile phase at a flow rate of 0.45 mL·min-1. The MS/MS analysis was performed with an electrospray ion source in positive mode under multiple reaction monitoring mode, and the calibration curve was used for quantification. The results showed that there were good linear relationships for the 41 PAAs in the concentration range of 0.08~50.00 μg·L-1, and their correlation coefficients(r2)were between 0.989 9~0.999 8. The limits of detection and limits of quantitation were in the ranges of 0.01~0.15 μg·L-1 and 0.04~0.30 μg·L-1, respectively. The relative standard deviations for the 41 prohibited compounds at three spiked levels were in the range of 2.31%~7.90%. At the 5 μg·L-1 level, the recoveries of 39 compounds among the 41 PAAs were above 80%. With simple pretreatment, a wide target range, high accuracy, and high sensitivity, the method is suitable for the analysis of PAAs in water. |
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