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| Effects of microplastics on the growth and structure of the mouse small intestine |
| Received:August 02, 2019 |
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| KeyWord:microplastics;mice;growth;small intestine structure |
| Author Name | Affiliation | E-mail | | KANG Kai | Guangdong Ocean University, Zhanjiang 524088, China | | | YANG Dan | Guangdong Ocean University, Zhanjiang 524088, China | | | HUANG Zhi-cheng | Guangdong Ocean University, Zhanjiang 524088, China | | | ZHANG Shi-min | Guangdong Ocean University, Zhanjiang 524088, China | | | FANG Ting-ting | Guangdong Ocean University, Zhanjiang 524088, China | | | JIANG Yin | Guangdong Ocean University, Zhanjiang 524088, China | | | WU Jiang | Guangdong Ocean University, Zhanjiang 524088, China | wujiang610@126.com |
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| Abstract: |
| To determine the effects of microplastics(MPs)on mouse growth and the intestinal structure, we selected the MPs polyethylene (MPs-PE)and polystyrene(MPs-PS)as raw materials, added respectively to Kunming white mouse chow at two concentrations:0.3%(3 g·kg-1 chow)and 3%(30 g·kg-1 chow). During feeding, we recorded the body weight and eating behavior of mice. After 27 days, mice were anatomized and the small intestine(duodenum, jejunum and ileum)was collected and used to make paraffin sections to observe the intestinal microstructure. Results showed that the diet and mental state of mice in both the control group and the MP addition group were normal. The body weight of the control group increased gradually during the feeding time, while the group with the MP additives showed an increased body weight in the early feeding times but stagnated and even declined in the later feeding times. The weight gain of the MP intake group was significantly slower than that in the control group(P<0.01), and showed a concentration dependence, though there was no significant difference in body weight between mice taking the two kinds of MPs. The intestinal microstructure showed that the small intestinal villi were swollen and structures were damaged, goblet cells were reduced, and there was hyperplasia of the submucosa. Thus, mice taking plastics show intestinal damage that lead to slower growth. |
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