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| Toxic organic substances influence enzymatic degradation of DNA and lateral transfer of antibiotic resistance genes |
| Received:December 07, 2019 |
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| KeyWord:toxic organic substances;DNA;binding;enzymatic degradation;antibiotic resistance genes;lateral/horizontal gene transfer |
| Author Name | Affiliation | E-mail | | HU Xiao-jie | Institute of Organic Contaminant Control and Soil Remediation, Nanjing Agricultural University, Nanjing 210095, China | | | QIN Chao | Institute of Organic Contaminant Control and Soil Remediation, Nanjing Agricultural University, Nanjing 210095, China | | | LIN Zhi-peng | Institute of Organic Contaminant Control and Soil Remediation, Nanjing Agricultural University, Nanjing 210095, China | | | GAO Yan-zheng | Institute of Organic Contaminant Control and Soil Remediation, Nanjing Agricultural University, Nanjing 210095, China | gaoyanzheng@njau.edu.cn |
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| Abstract: |
| Numerous types of toxic organic substances are spread widely in the environment. A large amount of DNA, which is the genetic material of life co-exist with the toxic organic substances in the contaminated areas. Due to the abuse of antibiotics, some of these DNA molecules are carrying antibiotic resistance genes(ARGs). The combined pollution of toxic organic substances and ARGs seriously endangers ecological safety and human health. How toxic organic substances influence the enzymatic degradation of DNA or the lateral transfer of ARGs becomes one of the hot spots in the field of environmental research, and some essential progress has been made in this field over the years. Toxic organic substances bind with DNA mainly through covalent interaction, noncovalent interaction, and the shearing interaction, which consequently alter the DNA structure; hence, affect the enzymatic degradation of DNA. Toxic organic substances could also affect the activity of DNA degrading enzyme or seize the enzyme action sizes on the DNA molecule, thus influencing the enzymatic degradation of DNA. Lateral transfer of ARGs in the environment is mainly in three ways:conjugation, transduction and transformation. It is influenced by toxic organic substances generally through the following mechanisms:regulating the mobile genetic elements, inducing cellular SOS response, stressing cells into a competent state, affecting the biofilm formation, altering the cell membrane permeability, and forming adducts with extracellular plasmid. How toxic organic substances inside cells influenced on the replication and expression of ARGs, is the key to deepening the mechanism of them influencing the lateral transfer of ARGs in the future. |
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