|
| The reproductive signal pathways induced by two cypermethrins in Caenorhabdities elegans |
| Received:February 26, 2019 |
| View Full Text View/Add Comment Download reader |
| KeyWord:cypermethrin;Caenorhabditis elegans;reproductive toxicity;signal transduction pathway |
| Author Name | Affiliation | E-mail | | YU Xue-feng | School of Resources and Environment, Anhui Agricultural University, Hefei 230036, China
Institute of Agricultural Engineering, Anhui Academy of Agricultural Science, Hefei 230031, China | | | GENG Wen-jing | School of Resources and Environment, Anhui Agricultural University, Hefei 230036, China
Institute of Agricultural Engineering, Anhui Academy of Agricultural Science, Hefei 230031, China | | | GUO Xiao-ying | Institute of Agricultural Engineering, Anhui Academy of Agricultural Science, Hefei 230031, China | gxy2@mail.ustc.edu.cn | | ZHU Jiang | School of Resources and Environment, Anhui Agricultural University, Hefei 230036, China | sy96123@163.com |
|
| Hits: 2252 |
| Download times: 1892 |
| Abstract: |
| In this study, Caenorhabdites elegans (C. elegans)was selected as a model organism with which to explore the effects of alphacypermethrin (α-CPM)and beta-cypermethrin (β-CPM)on reproduction from the concentrations of 0.005 to 3.2 mg·L-1. The signal transduction pathways were also further investigated. The results showed that germ cell death and germline apoptosis in C. elegans was affected by α-CPM and β-CPM at 0.05 mg·L-1, with dose effect. Further, the transduction of the reproductive injury signal was mainly dependent on the JNK MAPK signal transduction pathway and partially dependent on the p38 MAPK signal transduction pathway. Lower concentrations of α-CPM and β-CPM also induced DNA damage in the gonad of C. elegans, which mainly manifested as reduced brood size and hatching rate, with dose effect. These results indicate that exposure to α-CPM and β-CPM causes significant germ cell apoptosis in C. elegans. Also, the reproductive toxicity of β-CPM is higher than that of α-CPM. |
|
|
|
