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| Influences of nano-TiO2 on the neurotoxicity induced by galaxolide in the polychaeta Perinereis aibuhitensis |
| Received:November 03, 2017 |
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| KeyWord:galaxolide(HHCB);nano-TiO2;neurotoxicity;AChE |
| Author Name | Affiliation | | ZHANG Qian-ru | Key Laboratory of Pollution Ecology and Environmental Engineering, Institute of Applied Ecology, Chinese Academy of Sciences, Shenyang 110016, China
Guangdong Provincial Key Laboratory of Environmental Pollution Control and Remediation Technology, Guangzhou 510275, China | | JIANG Li-si | Key Laboratory of Pollution Ecology and Environmental Engineering, Institute of Applied Ecology, Chinese Academy of Sciences, Shenyang 110016, China
University of Chinese Academy of Sciences, Beijing 100049, China | | MU Wen-yan | Key Laboratory of Pollution Ecology and Environmental Engineering, Institute of Applied Ecology, Chinese Academy of Sciences, Shenyang 110016, China
University of Chinese Academy of Sciences, Beijing 100049, China | | WANG Jian-mei | Key Laboratory of Pollution Ecology and Environmental Engineering, Institute of Applied Ecology, Chinese Academy of Sciences, Shenyang 110016, China
University of Chinese Academy of Sciences, Beijing 100049, China | | LI Si-wen | Key Laboratory of Pollution Ecology and Environmental Engineering, Institute of Applied Ecology, Chinese Academy of Sciences, Shenyang 110016, China |
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| Abstract: |
| The number of reports on the ecotoxicological effects of emerging contaminants, especially emerging organic and inorganic combined contaminants, on estuary keystone species(polychaeta) is low. To understand the influence of these contaminants better, the relationships between toxicological indices(mortality and acetylcholinesterase(AChE) activity) and concentrations of contaminants(galaxolide(HHCB) and nano-TiO2) were examined in Perinereis aibuhitensis under laboratory conditions. The results of single contaminant stress indicated that the contaminants potentially were physiologically toxic to P.aibuhitensis. The estimated LC50(8 d) for HHCB and nano-TiO2 derived from the relationships between mortality and single contaminant concentrations were 313.21 mg·L-1 and 27.09 mg·L-1, respectively. The AChE activity of P.aibuhitensis was decreased, namely, the inhibition rate of AChE increased with an increase of the single HHCB exposure concentrations. However, the AChE activity of combined contaminants was significantly lower than that of single HHCB stress owing to the addition of nano-TiO2. The results implied that nano-TiO2 enhanced the sensitivity of AChE to HHCB, which exacerbated the neurotoxicity of HHCB to P.aibuhitensis. Thus, AChE had potential for becoming a useful biomarker of the neurotoxicity of emerging contaminants in the environment. The potential toxic effects of combined contamination should be paid more attention in the utilization of nano-TiO2 as a new material for environmental remediation. |
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