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| Effects of short-term exposure to hexabromocyclododecane (HBCD)on T3 and T4 of liver and brain in juvenile crimson snapper (Lutjanus erythopterus) |
| Received:January 26, 2016 |
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| KeyWord:hexabromocyclododecane;Lutjanus erythopterus;thyroid hormone;triiodothyronine;thyroxin |
| Author Name | Affiliation | E-mail | | CHEN Hai-gang | South China Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences
Key Laboratory of Fishery Ecology Environment, Guangdong Province
Key Laboratory of South China Sea Fishery Resources Exploitation & Utilization, Ministry of Agriculture
Scientific Observing and Experimental Station of South China Sea Fishery Resources & Environments, Ministry of Agriculture, Guangzhou 510300, China | | | SUN Li-wei | Ocean College, Zhejiang University of Technology, Hangzhou 310032, China | | | ZHANG Lin-bao | South China Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences
Key Laboratory of Fishery Ecology Environment, Guangdong Province
Key Laboratory of South China Sea Fishery Resources Exploitation & Utilization, Ministry of Agriculture
Scientific Observing and Experimental Station of South China Sea Fishery Resources & Environments, Ministry of Agriculture, Guangzhou 510300, China | | | ZHANG Zhe | South China Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences
Key Laboratory of Fishery Ecology Environment, Guangdong Province
Key Laboratory of South China Sea Fishery Resources Exploitation & Utilization, Ministry of Agriculture
Scientific Observing and Experimental Station of South China Sea Fishery Resources & Environments, Ministry of Agriculture, Guangzhou 510300, China | | | HU Ying | South China Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences
Key Laboratory of Fishery Ecology Environment, Guangdong Province
Key Laboratory of South China Sea Fishery Resources Exploitation & Utilization, Ministry of Agriculture
Scientific Observing and Experimental Station of South China Sea Fishery Resources & Environments, Ministry of Agriculture, Guangzhou 510300, China | | | CAI Wen-gui | South China Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences
Key Laboratory of Fishery Ecology Environment, Guangdong Province
Key Laboratory of South China Sea Fishery Resources Exploitation & Utilization, Ministry of Agriculture
Scientific Observing and Experimental Station of South China Sea Fishery Resources & Environments, Ministry of Agriculture, Guangzhou 510300, China | | | JIA Xiao-ping | South China Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences
Key Laboratory of Fishery Ecology Environment, Guangdong Province
Key Laboratory of South China Sea Fishery Resources Exploitation & Utilization, Ministry of Agriculture
Scientific Observing and Experimental Station of South China Sea Fishery Resources & Environments, Ministry of Agriculture, Guangzhou 510300, China | jxp60@tom.com |
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| Abstract: |
| Extensive applications of hexabromocyclododecane (HBCD) have caused environmental contamination. In this study, juvenile crimson snappers (Lutjanus erythopterus) were exposed to different concentrations of HBCD (8.6, 43.0, and 215 μg·L-1) for 24, 48, and 96 h to determine triiodothyronine (T3) and thyroxin (T4) levels and T3/T4 ratios in liver and brain tissues. Results showed that HBCD had ob vious disrupting effects on the thyroid of Lutjanus erythopterus. The exposures to 8.6 and 43.0 μg·L-1 significantly increased T3 and T4 lev els. An extremely significant induction effect on T3 and T4 was observed after 24 and 48 h exposures to 215 μg·L-1 (P<0.01), whereas ex tremely significant depression occurred under prolonged exposure to this concentration (P<0.01). Moreover, the liver T3/T4 ratio was lower in HBCD treatments than in the control. There were time-effect and dose-effect relationship. The brain T3/T4 ratio was higher under 24 and 48 h exposure, but lower under 96 h exposure to HBCD, as compared with that under the control. These results indicate that specific biomarkers in Lutjanus erythopterus, including liver T3, brain T3, liver T4, brain T4 and T3/T4 ratio, were sensitive enough to respond the stresses under short-term exposures to HBCD, and could provide important scientific basis for screening thyroid hormone disruptors and as sessing ecological risks. |
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