| 丛琳,武瑞,李银生.阿苯达唑对蚯蚓若干生化指标的影响[J].农业环境科学学报,2016,35(7):1264-1270. |
| 阿苯达唑对蚯蚓若干生化指标的影响 |
| Effects of albendazole on biochemical characteristics of earthworms |
| 投稿时间：2015-12-31 |
| DOI：10.11654/jaes.2016.07.006 |
| 中文关键词: 阿苯达唑 蚯蚓 抗氧化酶 谷胱甘肽转移酶 丙二醛 生物标记物 |
| 英文关键词: albendazole earthworm antioxidant enzyme glutathione-S-transferase malondialdehyde biomarker |
| 基金项目:国家自然科学基金项目（31172360） |
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| 摘要点击次数: 2871 |
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| 中文摘要: |
| 采用人工污染土壤的方法进行阿苯达唑的蚯蚓毒性试验，设计阿苯达唑的暴露浓度为0、50、100、200、400、600 mg·kg-1，暴露实验进行3、7、14、28 d后，分别检测蚯蚓体内超氧化物歧化酶（SOD）、过氧化物酶（POD）、过氧化氢酶（CAT）、谷胱甘肽转移酶（GST）活性和丙二醛（MDA）含量。结果表明，在供试浓度范围内，蚯蚓体内各生化指标对污染物暴露指示的敏感性存在差异，敏感性大小为：MDA > GST > SOD≈CAT > POD。400 mg·kg-1和600 mg·kg-1浓度下，阿苯达唑能够引起蚯蚓机体的氧化应激响应。这些敏感的生化指标可以用作阿苯达唑生态毒理的生物标志物。 |
| 英文摘要: |
| The toxicity of albendazole (ABZ) was investigated using earthworms and artificial soils contaminated with varying concentrations (0, 50, 100, 200, 400 and 600 mg·kg-1) of ABZ. The toxicity to the earthworms was assessed by measuring malondialdehyde (MDA) con tent and glutathione-S-transferase (GST), superoxide dismutase (SOD), peroxidase (POD) and catalase (CAT) activities of earthworms after exposure to ABZ for 3, 7, 14 and 28 days. The MDA content was positively correlated with ABZ concentrations; Such correlation was signifi cant at ABZ concentration of 400 mg·kg-1 after 3 days and 600 mg·kg-1 after 3, 7 and 14 days. The activities of SOD, CAT, POD and GST were negatively correlated with ABZ concentrations. The SOD and CAT activities were significantly inhibited by ABZ at 600 mg·kg-1 after 14 days, while POD activity was significantly suppressed by 600 mg·kg-1 after 7 days, and GST activity by 400 to 600 mg·kg-1 after 14 days. These sensitive biochemical indexes may be used as ecotoxicological biomarker of albendazole. |
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