| 张佳奇,徐艳,罗义,毛大庆.重金属协同选择环境细菌抗生素抗性及其机制研究进展[J].农业环境科学学报,2016,35(3):409-418. |
| 重金属协同选择环境细菌抗生素抗性及其机制研究进展 |
| Co-selection mechanisms of bacterial resistance to heavy metals and antibiotics |
| 投稿时间：2015-10-13 |
| DOI：10.11654/jaes.2016.03.001 |
| 中文关键词: 抗生素抗性 重金属抗性 协同选择抗性 协同选择抗性机制 |
| 英文关键词: antibiotic resistance heavy-metal resistance co-selection resistance co-selection resistance mechanism |
| 基金项目:国家自然科学基金项目(31270542,41473085) |
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| 中文摘要: |
| 抗生素的长期滥用,引起环境细菌耐药性不断增强,加速了抗生素抗性基因(Antibiotic resistance genes, ARGs)在环境中的传播扩散。在重金属污染的环境中,细菌不仅具备重金属抗性,并且具备多种抗生素抗性,抗生素抗性基因的污染水平也随之升高。在介绍重金属与抗生素抗性最新研究进展的基础上,阐述了环境细菌的抗生素抗性、重金属抗性及其相关抗性机制,并着重论述重金属和抗生素协同选择环境细菌耐药性及其机制。 |
| 英文摘要: |
| Excessive uses of antibiotics and increasingly serious pollution of heavy metals are continuously contributing to the emergence, persistence and transmission of antibiotic resistant genes(ARGs) in the environment. This paper summarized the latest research on antibiotic resistance and heavy metals resistance, and illustrated pollution status of ARGs and heavy-metal resistance genes and its coincidence mechanisms in bacteria in various environment. Bacteria were resistant not only to heavy metals, but also to multiple antibiotics in heavy-metal contaminated environment. Heavy-metal stresses caused elevated abundance of ARGs in natural rivers, sewage plants and livestock farms. Under heavy metal stresses, bacteria obtained antibiotic resistance through(a) co-resistance mechanism, i.e. antibiotic and heavy-metal resistance genes located on a same vector such as plasmids, integrons, and transposons;(b) cross-resistance mechanism such as efflux pumps taking effect when stimulated by heavy metals;(c)co-regulation mechanism, which relies on a two-component system and takes effect when stimulated by heavy metals. Finally, heavy metal stresses in the environment were promoting bacteria to obtain antibiotic resistance and to propagate ARGs among and in bacterial community. Nowadays, human beings are facing not only a serious pollution of antibiotics and heavy metals but a challenge of ARGs pollution. |
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